BioBam-15

Product Description

BioBAM-15 contains BAM15, a small-molecule mitochondrial protonophore used as a research tool to uncouple oxidative phosphorylation. It ferries protons across the inner mitochondrial membrane, dissipating membrane potential (Δψm) and weakening the proton motive force that normally drives ATP synthase.

BAM15 was discovered in screens explicitly looking for uncouplers with fewer confounds. Compared with FCCP at similar uncoupling potency, BAM15 was reported to avoid plasma membrane depolarization, show lower cytotoxicity, and stimulate respiration across a broader effective concentration range, which can make titrations and mechanistic readouts less “knife-edge.”

That profile is why BAM15 shows up in mitochondrial function experiments as an alternative to classical uncouplers, especially when investigators want to separate mitochondrial uncoupling from off-target electrophysiology at the cell surface.

Specifications