MOTS-c Description
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondria-derived peptide discovered in 2015 that functions as a mitochondrial-encoded regulatory signal. The 16-amino acid peptide is encoded by the mitochondrial genome within the 12S rRNA gene and represents an important link between mitochondrial function and metabolism. MOTS-c primarily targets skeletal muscle and acts as a metabolic regulator by activating the AMPK (AMP-activated protein kinase) pathway, which is crucial for cellular energy homeostasis.
Peptide Information
| Property | Value |
|---|---|
| Peptide Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
| Molecular Formula | C101H152N28O22S2 |
| Molecular Weight | 2174.6 g/mol |
| CAS Number | 1627580-64-6 |
| PubChem CID | 255386757 |
| Synonyms | 1627580-64-6, UNII-A5CV6JFB78, MOTS-c (human) (trifluoroacetate salt), A5CV6JFB78 |
